I hear you there, Justin! That's one reason I'd have to think about it before deciding to buy and use it: I'm allergic to poison ivy, and the active ingredient in urushi lacquer is the same thing that makes poison ivy itch - only more concentrated. I'd have to wear nitrile gloves, at the very least...
I just got done talking to Randy Black a little while ago, and he says he even has problems when refinishing older saya, just in removing the old urushi, since the dust from sanded urushi makes him break out and causes sinus problems if it gets past his dust mask.